K6PC-5 ACTIVATES SPHK1-NRF2 SIGNALING TO PROTECT NEURONAL CELLS FROM OXYGEN GLUCOSE DEPRIVATION/RE-OXYGENATION

K6PC-5 Activates SphK1-Nrf2 Signaling to Protect Neuronal Cells from Oxygen Glucose Deprivation/Re-Oxygenation

Background/Aims: New strategies are required to combat popularfilm.blog neuronal ischemia-reperfusion injuries.K6PC-5 is a novel sphingosine kinase 1 (SphK1) activator whose potential activity in neuronal cells has not yet been tested.Methods: Cell survival and necrosis were assessed with a Cell Counting Kit-8 assay and lactate dehydrogenase releas

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Case Report: Callosal disconnection syndrome manifesting as mixed frontal-callosal-posterior alien hand syndrome following extensive corpus callosum infarct [version 1; peer review: 2 approved]

Alien hand syndrome (AHS) is a rare neurological phenomenon first described by Goldstein over a century ago.The most widely moondrop quarks recognized variants in literature are frontal, callosal, and posterior AHS.AHS due to the corpus callosum lesion can occur alone or as part of callosal disconnection syndrome (CDS).This report presents a unique

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